Tacrolimus monohydrate 109581-93-3 aporo
Isanwo:T/T, L/C
Ipilẹṣẹ ọja:China
Ibudo Gbigbe:Beijing/Shanghai/Hangzhou
Agbara iṣelọpọ:1 kg / osù
Bere fun (MOQ):1g
Akoko asiwaju:3 Awọn ọjọ iṣẹ
Ipo ipamọ:Ti fipamọ ni itura, ibi gbigbẹ, iwọn otutu yara.
Ohun elo idii:vial, igo
Iwọn idii:1g/vial, 5/vial, 10g/vial, 50g/igo, 500g/igo
Alaye aabo:UN 2811 6.1/PG 3
Ọrọ Iṣaaju
Tacrolimus, jẹ oogun ajẹsara.Lẹhin asopo ohun ara eniyan allogeneic, eewu ti ijusile eto ara jẹ iwọntunwọnsi.Lati dinku eewu ti ijusile eto ara, a fun tacrolimus.O tun le ta oogun naa bi oogun ti agbegbe ni itọju ti awọn aarun alaja T-cell gẹgẹbi àléfọ ati psoriasis.O le ṣee lo lati ṣe itọju ailera oju ti o gbẹ ni awọn ologbo ati awọn aja.
Tacrolimus ṣe idiwọ calcineurin, eyiti o ni ipa ninu iṣelọpọ interleukin-2, moleku kan ti o ṣe agbega idagbasoke ati ilọsiwaju ti awọn sẹẹli T, gẹgẹ bi apakan ti idahun ti ajẹsara ti ẹkọ (tabi adaṣe) ti ara.
Ni pato (USP43)
| Nkan | Sipesifikesonu |
| Ifarahan | Funfun tabi fere funfun okuta lulú |
| Idanimọ | IR, HPLC |
| Solubility | Tiotuka pupọ ni methanol, tiotuka larọwọto ni N, N dimethylformamide ati ninu oti, ni iṣe ni tiotuka ninu omi. |
| Aloku lori iginisonu | ≤0.10% |
| Organic impurities (ilana-2) | Ascomycin 19-epimer ≤0.10% |
| Ascomycin ≤0.50% | |
| Desmethyl tacrolimus ≤0.10% | |
| Tacrolimus 8-epimer ≤0.15% | |
| Tacrolimus 8-propyl afọwọṣe ≤0.15% | |
| Aimọ aimọ -I ≤0.10% | |
| Aimọ aimọ -II ≤0.10% | |
| Aimọ aimọ -III ≤0.10% | |
| Lapapọ awọn idoti ≤1.00% | |
| Yiyi opitika (lori bi ipilẹ) (10mg/ml ni N, Ndimethylformamide) | -110,0 ° ~ -115,0 ° |
| Akoonu omi (nipasẹ KF) | ≤4.0% |
| Awọn olomi ti o ku (nipasẹ GC) | Acetone ≤1000ppm (Ninu ile) |
| Di-isopropyl ether ≤100ppm (Ninu ile) | |
| Ethyl ether ≤5000ppm | |
| Acetonitrile ≤410ppm | |
| Toluene ≤890ppm | |
| Hexane ≤290ppm | |
| Idanwo microbial (ninu ile) | Lapapọ iṣiro makirobia aerobic ≤100cfu/gm |
| Lapapọ iwukara ati kika mimu ≤10cfu/gm | |
| Awọn ohun alumọni pato (Pathogens) (E.coil, salmonella sps., S.aureus. Pseudomonas aeruginosa) ko yẹ ki o wa | |
| Igbeyewo (nipasẹ HPLC) (lori ipilẹ anhydrous ati epo) | 98% ~ 102% |
